The University of Colorado Hospital project included of the expansion of the existing inpatient bed count and existing diagnostic and treatment areas, a much larger Emergency Department, the construction of two new parking structures (one for staff and one for outpatients) and all associated building and site infrastructure. The construction included 409,373 gross square feet of new finished space, 249,530 gross square feet of new unfinished space and 53,850 gross square feet of renovation space.

Along with the expansion of the inpatient bed count and diagnostic areas, renovation and additional capacity was needed to treat the growing number of cancer patients at the University of Colorado Hospital. The addition included increasing the 108,000 square foot Cancer Center building by 38,600 square feet of new space through the partial addition of a fourth floor and expansion at the north end of the existing three story building. In addition to the new space, 14,100 square feet of existing space was renovated and reconfigured to improve operational efficiency.